3-(Methylsulphonyl)aniline → HCID 11540592, compound

HRID 2224563Notes

Reaction equation

HRID 2224563 reaction equation
[CH:1]1([C:4]2[N:9]3[N:10]=[CH:11][C:12]([C:13]([OH:15])=O)=[C:8]3[N:7]=[C:6]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH:5]=2)[CH2:3][CH2:2]1.[CH3:26][S:27]([C:30]1[CH:31]=[C:32]([NH2:36])[CH:33]=[CH:34][CH:35]=1)(=[O:29])=[O:28]>>[CH3:26][S:27]([C:30]1[CH:31]=[C:32]([NH:36][C:13]([C:12]2[CH:11]=[N:10][N:9]3[C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:5][C:6]([C:16]4[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:24])[F:25])=[CH:18][CH:17]=4)=[N:7][C:8]=23)=[O:15])[CH:33]=[CH:34][CH:35]=1)(=[O:28])=[O:29]

Participants

3

Reactant 2

HCID 4280293-(Methylsulphonyl)anilineHCID 666503207-Cyclopropyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11540592HCID 11540592, compound

Procedure

The title compound was prepared from 7-cyclopropyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.29) and 3-methanesulfonyl-phenylamine according to general procedure II. Pale-yellow solid. MS (ISP) 501.3 [(M+H)+]; mp 231-234° C.

Sources & evidence

ORD record
ord-aa885c970d90406fb20eb9983321a841
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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