Sodium Chloride → HCID 58597404, compound

Participants

Reaction Conditions

Reaction Steps

N-(2-Bromo-phenyl)4-methoxy-benzenesulfonamide (0.34 g, 0.99 mmol) was dissolved in dimethoxyethane (4 mL) and tetrakis(triphenylphosphine)palladium (0) (0.23 g, 0.2 mmol) was added. 2-acetylphenylboronic acid (0.16 g, 0.99 mmol), dissolved in ethanol (1 mL), was added, followed by aqueous sodium carbonate (4.2 mL, 2 M). The reaction mixture was heated at 100° C. for 14 hours. The mixture was diluted with a saturated, aqueous sodium chloride solution (200 mL) and extracted with dichloromethane (4×30 mL). The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to yield a residue. The crude product was purified by silica gel chromatography (1:9 to 3:7 ethyl acetate:hexane) to afford the title product.

Provenance & Evidence