Isobutyraldehyde → HCID 59717692, compound

Participants

Reaction Steps

3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester (3 g, 16.1 mmol) was added to a solution of isobutyraldehyde (1.61 mL, 17.7 mmol) and 10% Pd/C (360 mg) in ethanol (60 mL) and the reaction mixture left under about 415 kPa (about 60 psi) of hydrogen gas for 18 hours. The reaction mixture was filtered through Arbocel®, washing through thoroughly with ethyl acetate. The filtrate was concentrated in vacuo and the crude product purified by column chromatography on silica gel eluting with ethyl acetate:pentane 1:1 to yield the title product, 2.8 g, (73%).

Provenance & Evidence