Diethyl 2-(2-phenyl-2-propylpentanoyl)malonate → Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

HRID 2224787Notes

Reaction equation

HRID 2224787 reaction equation
[CH3:1][C:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:16])[C:3]([CH:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:4].C1(C(CCC)(CCC)C(C(C(OCC)=O)C(OCC)=O)=O)C=CC=CC=1>>[OH:13][C:11]1[C:18]2[C:17](=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:2]([CH3:16])([CH3:1])[C:3](=[O:4])[C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 11552281Diethyl 2-(2-phenyl-2-propylpentanoyl)malonateHCID 12369090Diethyl 2-(2-methyl-2-phenylpropanoyl)malonate

Product 1

HCID 57604805Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

Procedure

The title compound was prepared according to the procedure of Example 1F, substituting the product of Example 9D for the product of Example 1E. 1H NMR (300 MHz, CDCl3): δ 15.16, 15.03 (two s, 1 H), 8.18 (m, 1 H), 7.52 (m, 3 H), 4.47 (m, 2 H), 1.66 (s, 3 H), 1.51 (s, 3 H), 1.45 (t, J=6.62 Hz, 3 H).

Sources & evidence

ORD record
ord-e5bc8d90ce1449adaeed56fea80b2629
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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