HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[bis(methylsulfanyl)methylene]-4,4-dibutyl-1,3(2H,4H)-naphthalenedione → Tert-butyl 3-(7-fluoro-1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4h-1,2,4-benzothiadiazin-7-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[bis(methylsulfanyl)methylene]-4,4-dibutyl-1,3(2H,4H)-naphthalenedione | HCID 11211104 | — |
| Reactant | 2-[Bis(methylthio)methylene]-7-fluoro-4,4-dipropylnaphthalene-1,3(2h,4h)-dione | HCID 11485414 | — |
| Reactant | (4-Amino-3-sulfamoyl-phenyl)-carbamic acid tert-butyl ester | HCID 59805694 | — |
| Reactant | 2-Amino-5-(benzyloxy)benzenesulfonamide | HCID 67063986 | — |
| Product | Tert-butyl 3-(7-fluoro-1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4h-1,2,4-benzothiadiazin-7-ylcarbamate | HCID 136384912 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 5D, substituting the compound of Example 14H for the compound of Example 5C, and the compound of Example 17A for the compound of Example 2D. 1H NMR (300 MHz, DMSO-d6): δ 0.62 (m, 8 H) 0.91 (m, 2 H) 1.47 (d, J=17.28 Hz, 9 H) 1.93 (m, 2 H) 2.10 (m, 2 H) 7.63 (m, 5 H) 8.03 (s, 1 H) 9.77 (s, 1 H) 14.21 (s, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378414B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-4e86dee7931344f9bf94aa455164a549 |
| Source note | uspto-grants-2008_05 |