Sodium Hydroxide → HCID 68873063, compound

HRID 2224829Notes

Reaction equation

HRID 2224829 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:15])([CH2:12][CH2:13][CH3:14])[C:4](=[O:16])[C:3]=1[C:17]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([O:27][CH2:28][C:29]([NH2:31])=[O:30])=[CH:26][C:20]=2[S:19](=[O:33])(=[O:32])[N:18]=1.[OH-].[Na+:35]>O>[NH2:31][C:29](=[O:30])[CH2:28][O:27][C:25]1[CH:24]=[CH:23][C:21]2[NH:22][C:17]([C:3]3[C:4](=[O:16])[C:5]([CH3:15])([CH2:12][CH2:13][CH3:14])[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:2]=3[O-:1])=[N:18][S:19](=[O:32])(=[O:33])[C:20]=2[CH:26]=1.[Na+:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135496250HCID 135496250, compound

Product 1

HCID 68873063HCID 68873063, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 26I (0.096 g) in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.166 mL, 0.166 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.078 g, 79% two steps). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.66 (m, 3 H) 1.32 (m, 4 H) 1.63 (m, 2 H) 2.08 (m, 1 H) 4.47 (m, 2 H) 7.30 (m, 8 H) 8.00 (m, 1 H) 15.38 (m, 1 H). MS (ESI−) m/z 468 (M−H)−.

Sources & evidence

ORD record
ord-43bc0d3668154753b49bcba4a0df6d6b
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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