Sodium Hydroxide → HCID 68871568, compound

HRID 2224835Notes

Reaction equation

HRID 2224835 reaction equation
[CH2:1]([C:5]1([CH3:34])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([OH:15])=[C:7]([C:16]2[NH:21][C:20]3[CH:22]=[CH:23][C:24]([O:26][CH2:27][C:28]([NH2:30])=[O:29])=[CH:25][C:19]=3[S:18](=[O:32])(=[O:31])[N:17]=2)[C:6]1=[O:33])[CH2:2][CH2:3][CH3:4].[OH-].[Na+:36]>O>[NH2:30][C:28](=[O:29])[CH2:27][O:26][C:24]1[CH:23]=[CH:22][C:20]2[NH:21][C:16]([C:7]3[C:6](=[O:33])[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])([CH3:34])[C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[C:8]=3[O-:15])=[N:17][S:18](=[O:31])(=[O:32])[C:19]=2[CH:25]=1.[Na+:36]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135507537HCID 135507537, compound

Product 1

HCID 68871568HCID 68871568, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 27I in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.159 mL, 0.158 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.075 g, 64% two steps). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.56 (m, 1 H) 0.69 (m, 3 H) 0.87 (m, 1 H) 1.07 (m, 2 H) 1.28 (m, 1 H) 1.38 (m, 3 H) 1.57 (m, 1 H) 1.71 (m, 1 H) 2.13 (m, 1 H) 4.48 (m, 2 H) 7.29 (m, 6 H) 8.05 (m, 1 H) 15.40 (m, 1 H). MS (ESI−) m/z 482 (M−H)−.

Sources & evidence

ORD record
ord-6e7b26c972784c7cbbf7ae517f80503a
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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