Sodium Hydroxide → HCID 68871738, compound

HRID 2224841Notes

Reaction equation

HRID 2224841 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:17])([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:18])[C:3]=1[C:19]1[NH:24][C:23]2[CH:25]=[CH:26][C:27]([O:29][CH2:30][C:31]([NH2:33])=[O:32])=[CH:28][C:22]=2[S:21](=[O:35])(=[O:34])[N:20]=1.[OH-].[Na+:37]>O>[NH2:33][C:31](=[O:32])[CH2:30][O:29][C:27]1[CH:26]=[CH:25][C:23]2[NH:24][C:19]([C:3]3[C:4](=[O:18])[C:5]([CH3:17])([CH2:12][CH2:13][CH:14]([CH3:15])[CH3:16])[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:2]=3[O-:1])=[N:20][S:21](=[O:34])(=[O:35])[C:22]=2[CH:28]=1.[Na+:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135518347HCID 135518347, compound

Product 1

HCID 68871738HCID 68871738, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 28I (0.099 g) in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.200 mL, 0.199 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.100 g, 85% two steps). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.43 (m, 1 H) 0.75 (m, 7 H) 1.31 (m, 5 H) 1.64 (m, 2 H) 2.14 (m, 1 H) 4.45 (m, 2 H) 7.31 (m, 6 H) 8.05 (m, 1 H) 15.42 (m, 1 H). MS (ESI−) m/z 496 (M−H)−.

Sources & evidence

ORD record
ord-50ec672ef5444a51981c371e0fd2d097
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

Loading…