HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2224844Generated: October 30, 2026
2-Aminobenzenesulfonamide → 1-butyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-methylnaphthalen-2(1H)-one
https://huagongshe.com/reaction/2224844
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminobenzenesulfonamide | HCID 72894 | — |
| Reactant | 2-[Bis(methylthio)methylene]-4-butyl-4-methylnaphthalene-1,3(2h,4h)-dione | HCID 11325122 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-butyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-methylnaphthalen-2(1H)-one | HCID 135423313 | 86% |
Reaction Steps
A solution of Example 27F (0.064 g, 0.191 mmol) and 2-amino-benzenesulfonamide (0.035 g, 0.201 mmol) in toluene (7 mL) was refluxed for 6 hours. The solution was cooled to 25° C. and concentrated in vacuo. The residue was chromatographed on silica gel eluting with hexane followed by 20% and 30% ethyl acetate in hexane to give the desired product (0.067 g, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07378414B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-04809c1b967f4855ad44cb8b9eaf0504 |
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| Source note | uspto-grants-2008_05 |
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