Sodium Hydroxide → HCID 68870362, compound

HRID 2224847Notes

Reaction equation

HRID 2224847 reaction equation
[O:1]=[S:2]1(=[O:30])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4]([C:12]2[C:13](=[O:29])[C:14]([CH3:28])([CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])[C:15]3[C:20]([C:21]=2[OH:22])=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:3]1.[OH-].[Na+:32]>O>[O:30]=[S:2]1(=[O:1])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4]([C:12]2[C:13](=[O:29])[C:14]([CH3:28])([CH2:23][CH2:24][CH:25]([CH3:26])[CH3:27])[C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21]=2[O-:22])=[N:3]1.[Na+:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135431633HCID 135431633, compound

Product 1

HCID 68870362HCID 68870362, compoundYield 109.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 31A (0.105 g) in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.248 mL, 0.2247 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.110 g, 99%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.47 (m, 1 H) 0.68 (m, 6 H) 0.80 (m, 1 H) 1.28 (m, 1 H) 1.39 (m, 3 H) 1.73 (m, 1 H) 2.15 (m, 1 H) 7.29 (m, 3 H) 7.50 (m, 3 H) 7.65 (m, 1 H) 8.05 (m, 1 H) 15.48 (m, 1 H). MS (ESI−) m/z 423 (M−H)−.

Sources & evidence

ORD record
ord-34806ee0bb0a4f4e97c7ac72fbba8ab2
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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