Sodium Hydroxide → HCID 44456402, compound

HRID 2224850Notes

Reaction equation

HRID 2224850 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:15])([CH2:12][CH2:13][CH3:14])[C:4](=[O:16])[C:3]=1[C:17]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([NH:27][S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][C:20]=2[S:19](=[O:33])(=[O:32])[N:18]=1.[OH-].[Na+:35]>O>[CH3:15][C:5]1([CH2:12][CH2:13][CH3:14])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O-:1])=[C:3]([C:17]2[NH:22][C:21]3[CH:23]=[CH:24][C:25]([NH:27][S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][C:20]=3[S:19](=[O:33])(=[O:32])[N:18]=2)[C:4]1=[O:16].[Na+:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135509839HCID 135509839, compound

Product 1

HCID 44456402HCID 44456402, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 32C (0.049 g) in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.099 mL, 0.098 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.043 g, 86%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.64 (m, 4 H) 0.89 (m, 1 H) 1.38 (m, 3 H) 1.68 (m, 1 H) 2.10 (m, 1 H) 2.93 (m, 3 H) 7.28 (m, 3 H) 7.45 (m, 3 H) 8.05 (m, 1 H) 9.85 (m, 1 H) 15.42 (m, 1 H). MS (ESI−) m/z 488 (M−H)−.

Sources & evidence

ORD record
ord-adcbbf0a731746559c58f33ce9625a77
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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