反应详情

To a suspension of lithium aluminum hydride (0.2 g) in 50 ml of ether at 0° C. was added dropwise a solution of ethyl 4,4'-dimethylbiphenyl-3-carboxylate (2 g) in ether. After the addition was complete, the mixture was allowed to slowly rise to room temperature, and stirred for 2 hours. Excess reagent was hydrolysed with wet sodium sulfate. The mixture was filtered, the solvent evaporated from the filtrate under reduced pressure, and the residue flash-chromatographed on silica gel, eluting with 25% ethyl acetate in heptane, to yield 3-hydroxymethyl-4,4'-dimethylbiphenyl as an oil.

1. additionAfter the addition
2. customto slowly rise to room temperature
3. filtrationThe mixture was filtered
4. customthe solvent evaporated from the filtrate under reduced pressure
5. customthe residue flash-chromatographed on silica gel
6. washeluting with 25% ethyl acetate in heptane