Ethyl 1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydro-2-naphthalenecarboxylate → 1,1-dipropyl-4-hydroxy-2(1H)-naphthalenone

HRID 2224926Notes

Reaction equation

HRID 2224926 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:15][CH2:16][CH3:17])([CH2:12][CH2:13][CH3:14])[C:4](=[O:18])[C:3]=1C(OCC)=O.C(C1(CCCC)C2C(=CC=CC=2)C(O)=C(C(OCC)=O)C1=O)CCC>>[CH2:15]([C:5]1([CH2:12][CH2:13][CH3:14])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[CH:3][C:4]1=[O:18])[CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 54724640Ethyl 1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydro-2-naphthalenecarboxylateHCID 68871457Ethyl 4,4-dibutyl-1-hydroxy-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

Product 1

HCID 688716431,1-dipropyl-4-hydroxy-2(1H)-naphthalenone

Procedure

The title compound was prepared according the procedure of Example 5B, substituting the product of Example 1F for the product of Example 4F. 1H NMR (300 MHz, CDCl3) δ ppm 0.55 m, 2 H) 0.67 m, 4.8 H) 0.79 m, 1.2 H) 0.98 m, 2 H) 1.78 m, 2 H) 2.19 m, 2 H) 3.69 (s, 0.4H) 6.13 (s, 0.8H) 7.41 m, 2 H) 7.56 m, 0.8 H) 7.67 (m, 0.2H) 8.07 (m, 0.2H) 8.13 m, 0.8 H).

Sources & evidence

ORD record
ord-b833e59c44714abdb8b147e7a66c6368
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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