Pentanoic Acid → HCID 59773977, compound

HRID 2224930Notes

Reaction equation

HRID 2224930 reaction equation
[C:1]([OH:7])(=O)[CH2:2][CH2:3][CH2:4][CH3:5].[Cl:8][S:9]([N:12]=C=O)(=[O:11])=[O:10]>C1C=CC=CC=1>[C:1]([NH:12][S:9]([Cl:8])(=[O:11])=[O:10])(=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 7991Pentanoic AcidHCID 70918Chlorosulfonyl isocyanate

Product 1

HCID 59773977HCID 59773977, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

n-Pentanoic acid (1.02 g, 10 mmol) was added slowly dropwise to chlorosulfonyl isocyanate (1.42 g, 10 mmol), with ice/water bath cooling as required to maintain gentle gas evolution. After the addition was complete, the residue was taken up in benzene (10 mL) and the mixture concentrated in vacuo to provide the title compound (2.0 g, quantitative) as a crystalline, hygroscopic solid.

Workup

  1. temperaturecooling
  2. temperatureto maintain gentle gas evolution
  3. additionAfter the addition
  4. concentrationthe mixture concentrated in vacuo

Sources & evidence

ORD record
ord-65bb672f8fa3437aad982fba5acac426
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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