Propionic Acid → HCID 20138741, compound

HRID 2224933Notes

Reaction equation

HRID 2224933 reaction equation
[CH3:1][CH2:2][C:3]([OH:5])=O.[Cl:6][S:7]([N:10]=C=O)(=[O:9])=[O:8]>C1C=CC=CC=1>[C:3]([NH:10][S:7]([Cl:6])(=[O:9])=[O:8])(=[O:5])[CH2:2][CH3:1]

Participants

4

Reactant 2

HCID 1032Propionic AcidHCID 70918Chlorosulfonyl isocyanate

Product 1

HCID 20138741HCID 20138741, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

n-Propionic acid (0.741 g, 10 mmol) was added slowly dropwise to chlorosulfonyl isocyanate (1.42 g, 10 mmol), with ice/water bath cooling as required to maintain gentle gas evolution. After the addition was complete, the residue was taken up in benzene (10 mL) and the mixture concentrated in vacuo to provide the title compound (1.71 g, quantitative) as a crystalline, hygroscopic solid.

Workup

  1. temperaturecooling
  2. temperatureto maintain gentle gas evolution
  3. additionAfter the addition
  4. concentrationthe mixture concentrated in vacuo

Sources & evidence

ORD record
ord-1de785267e6a4d519a34a5b5e9a475a1
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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