HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acryloyl chloride → 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | Methacryloyl chloride | HCID 13528 | — |
| Reactant | 5,5,5-Trifluoro-4-(trifluoromethyl)pentane-1,4-diol | HCID 21895362 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Reactant | HCID 178418348 | HCID 178418348 | — |
| Product | 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate | HCID 58999836 | 86% |
Reaction Steps
1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate was synthesized according to the method of Example 4 but substituting (a) 60 g (0.25 mol) of 1,1,1-trifluoro-2-trifluoromethyl-4-methyl-2,5-pentanediol (2) for diol (4), (b) 311 mL (0.497 mol) of methyllithium (1.6M in ether) for the n-butyllithium, and (c) 22.3 g (0.248 mol) of acryloyl chloride for the methacryloyl chloride, to yield 58 g (86%) of the title compound as a clear colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378542B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-8a1c5f69a78e4412a010d0c7e6e3c981 |
| Source note | uspto-grants-2008_05 |