HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Pyrrolidine-2-carbaldehyde-O-benzyl-oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(Benzyloxyimino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86601086 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Pyrrolidine-2-carbaldehyde-O-benzyl-oxime | HCID 72562396 | — |
Reaction Steps
The solution of 2-(benzyloxyimino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.50 g, 4.92 mmole) and TFA (10 ml) in dichloromethane (10 ml) is stirred for 2 hours at room temperature. Solvent is removed. The crude product is carried to next step without further purification. M+H+=205.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207183B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-d6e593a8eff940fbba4a5c6d74d47814 |
| Source note | uspto-grants-2012_06 |