Lithium Hydroxide → Lithium 3-bromo-5-tert-butylbenzoate

Participants

Reaction Steps

Preparation C12, Step 1: A solution of the commercially available methyl 3-bromo-5-tert-butylbenzoate (87 mg, 0.32 mmol) in THF (2 mL) was treated with 0.5 N aqueous lithium hydroxide (0.71 mL, 0.35 mmol), and the mixture was stirred at room temperature for six hours. The THF was stripped in-vacuo, and the aqueous was freeze dried to yield 112 mg of light brown solids. This material was used as-is in the next step.

Provenance & Evidence