Hydrochloric Acid → HCID 178524079, compound

Participants

Reaction Steps

Preparation C13, Step 3: 5-Adamantan-1-yl-2H-pyrazole-3-carboxylic acid ethyl ester (1.00 g, 3.64 mmol, 1 eq.) was dissolved in THF (20 mL) at RT then 1.000 N NaOH (7.29 mL, 7.29 mmol, 2 eq.) was added. Stirred overnight. Stripped off the THF in vacuo then adjusted the pH=3 with 1 N HCl. Extracted 3 times with ethyl acetate (25 mL). The organic layers were combined, dried and stripped to give 830 mg of 5-adamantan-1-yl-2H-pyrazole-3-carboxylic acid as an off-white solid. MS found: (M+H)+=247.

Provenance & Evidence