Acetic Acid → HCID 178518377, compound

Participants

Reaction Conditions

Reaction Steps

Preparation D9, Step 1: 2-Amino-5-chlorobenzamide (Avocado) (3.00 g, 17.5 mmol, 1.0 eq.) was suspended in 105 mL of H2O and 1.75 mL of HOAc at 25° C. A 12 mL solution of H2O and sodium cyanate (2.80 g, 43.0 mmol, 2.46 eq.) was then added slowly. Stirred at 35° C. for 1 hour. Added 31.26 mL of 1.0 N NaOH slowly. Solids precipitated. Cooled to 0° C. Carefully added conc. HCl to pH=3. Filtered solids. Solids were then stirred in Et2O then refiltered and pumped under high vacuum to give 3.36 grams of 6-chloro-quinazoline-2,4-diol as a tan solid. MS found: (M+H)+=197.

Provenance & Evidence