2-Amino-5-bromobenzoic acid → HCID 178517953, compound

Participants

Reaction Steps

Preparation D12, Step 1: A mixture of 2-amino-5-bromobenzoic acid (5.7 g, 24.78 mmol) and formamidine acetate (5.2 g, 49.5 mmol) in 2-ethoxyethanol (50 mL) was heated at reflux for 4 h. The reaction was cooled to room temperature, allowed to stand overnight, then diluted with diethyl ether (20 mL) to further precipitate the product. The solids were collected by filtration, rinsed with 2-ethoxyethanol (10 mL), diethyl ether (2×50 mL), and air dried to yield 4.4 g of 6-bromoquinazolin-4-ol as a tan solid. MS (ES+)=225/227 (M+H+).

Provenance & Evidence