反应详情

温度

0 °C

To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.

1. temperaturethe mixture refluxed for 4 hours
2. customgiving a precipitate
3. filtrationthe solid filtered off
4. washwashed with ethanol
5. customdried under reduced pressure