HCID 178457353, compound → HCID 178457352, compound

Participants

Reaction Steps

Example 1 h, Step 4: cis-{[4-(Isopropyl-methyl-amino)-cyclohexylcarbamoyl]-methyl}-carbamic acid benzyl ester (1.86 g), methanol (20 mL), and 20% Pd(OH)2 (400 mg) were hydrogenated until completion by TLC on a Parr shaker at 50 psi. Filtration through fiberglass filter paper under nitrogen and removal of solvent in vacuo yielded 870 mg of cis-2-amino-N-[4-(isopropyl-methyl-amino)-cyclohexyl]-acetamide. MS found: (M+H)+=227.

Provenance & Evidence