Hydrochloric Acid → HCID 178479272, compound

Participants

Reaction Steps

tert-Butyl cis-4-(2-(3-(trifluoromethyl)benzamido)acetamido)cyclohexylcarbamate hydrochloride salt (350 mg, 0.79 mmol, 1 eq) was dissolved in dioxane (5 mL) at room temperature then 4N HCl (1.97 mL, 7.9 mmol, 10 eq) was added. Stirred for 20 hours. The reaction was stripped 4 times from 1:1 THF/methylene chloride (20 mL) to give N-(2-(cis-4-amino-cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide hydrochloride (300 mg) as a white amorphous solid. MS found: (M+H)+=344.32.

Provenance & Evidence