HCID 69286608, compound → HCID 69285468, compound

Participants

Reaction Steps

A sample of [(1S,2R,4R)-[4-tert-butoxycarbonylamino-2-(3-methyl-but-1-enyl)-cyclohexyl]-carbamic acid benzyl ester (0.24 g, 0.57 mmol) was dissolved in methanol (8 mL) and the resultant solution was charged with 5% Pd/C, Degussa (47 mg). The flask was evacuated and back-filled with hydrogen; this was repeated three times. The reaction was stirred under 1 atm of hydrogen for 14 h before being filtered and concentrated in vacuo to afford (1R,3R,4S)-[4-amino-3-(3-methyl-butyl)-cyclohexyl]-carbamic acid tert-butyl ester. MS found: (M+H)+=285.3.

Provenance & Evidence