Triethylamine → HCID 69285658, compound

Participants

Reaction Steps

A sample of 2-amino-N-((1S,2R,4R)-2-butyl-4-(tert-butylamino)cyclohexyl)acetamide was combined with 3-Trifluoromethylbenzoic acid (1 equivalent), EDCI (1 equivalent), HOBT (1.1 equivalents), and triethylamine (1 equivalent) in 2 mL of CH2Cl2 was stirred at room temperature overnight. The reaction mixture was directly chromatographed on silica gel (eluting with 2-8% NH4OH/MeOH/CH2Cl2) to give N-(2-((1S,2R,4R)-2-butyl-4-(tert-butylamino)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide as a white solid. MS found: (M+H)+=456.47; 1H NMR (400 MHz, CDCl3) δ(TMS): 0.83-1.98 (m, 25H), 2.67-2.79 (m, 1H) 4.12-4.28 (m, 3H), 6.80-6.90 (m, 1H), 7.49-7.63 (m, 2H), 7.78-7.84 (m, 1H), 8.00-8.06 (m, 1H), 8.15 (s, 1H).

Provenance & Evidence