HCID 86596944, compound → HCID 86596945, compound

Participants

Reaction Steps

A solution of tert-butyl (1R,3S,4S)-4-benzyloxycarbonylamino-3-(prop-1-en-2-yl)cyclohexylcarbamate (1.1 g) in MeOH (10 mL) was charged with 10% Pd/C, Degussa (300 mg). The reaction flask was evacuated and then back-filled with hydrogen; this was repeated three more times. The reaction was stirred under 1 atm of H2 for 12 h and then filtered and concentrated to provide tert-butyl (1R,3S,4S)-4-amino-3-isopropylcyclohexylcarbamate (780 mg). MS (ES+)=257.3 (M+H)+.

Provenance & Evidence