Dimethylamine → HCID 69284627, compound

Participants

Reaction Steps

A solution of 2-(2,6-dichloroquinazolin-4-ylamino)-N-((1S,2R,4R)-4-(ethyl(isopropyl)amino)-2-(methoxymethyl)cyclohexyl)acetamide (61 mg) in tetrahydrofuran (2 mL) was treaded with dimethylamine (2 M in tetrahydrofuran, 80 μL) and the mixture was heated at reflux overnight. Additional dimethylamine solution (0.825 mL) was added and heating was continued for 3 more days. Concentration under vacuum and purification by reverse phase HPLC and lyophilization provided the bis-trifluoroacetic acid salt of the title product, 2-(6-chloro-2-(dimethylamino)quinazolin-4-ylamino)-N-((1S,2R,4R)-4-(ethyl(isopropyl)amino)-2-(methoxymethyl)cyclohexyl)acetamide, as a white powder (54 mg). MS found: (M+H)+=491.7.

Provenance & Evidence