Benzyloxycarbonylglycine → HCID 69284585, compound

Participants

Reaction Steps

A solution of tert-butyl 3-((1R,2S,5R)-2-amino-5-(tert-butoxycarbonylamino)cyclohexyl)propanoate (90 mg) and 2-(benzyloxycarbonylamino)acetic acid (55 mg) in dichloromethane (2 mL) was treated sequentially with diisopropylethylamine (92 μL), 1-hydroxybenzotriazole hydrate (45 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (61 mg). The mixture was stirred at rt for 20 h, then was diluted with dichloromethane, washed sequentially with 1 M aqueous HCl, saturated aqueous NaHCO3 and water, dried over Na2SO4 and concentrated under vacuum to provide tert-butyl 3-((1R,2S,5R)-2-(2-(benzyloxycarbonylamino)acetamido)-5-(tert-butoxycarbonylamino)cyclohexyl)propanoate as a pale yellow gum (125 mg). MS found: (M+H)+=534.5.

Provenance & Evidence