Hydrochloric Acid → HCID 86596963, compound

Participants

Reaction Steps

A solution of benzyl ((7R,8S)-7-(isopropylsulfonylmethyl)-1,4-dioxa-spiro[4.5]dec-8-yl)-carbamate (2.3 g, 5.6 mmol) in acetone (30 ml) is treated with 5 N HCl (30 ml) and heated to reflux for 2 hrs. The The mixture is concentrated on a rotary evaporator and the residue neutralized with 1 N NaOH and extracted into CH2Cl2. The organic extracts were washed with water, brine, and the solvent remove under vacuum to give 2.0 g of benzyl (1S,2R)-2-(isopropylsulfonylmethyl)-4-oxocyclohexylcarbamate. This is used without further purification.

Provenance & Evidence