Trifluoroacetic acid → HCID 69286125, compound

Participants

Reaction Steps

A solution of Step 1 product (120 mg) in CH2Cl2 is treated with CF3COOH (7 ml) and stirred at room temperature for 2 hours. The solution was evaporated and the residue neutralized with 1 N NaOH and extracted into CH2Cl2. The extract was washed with water, brine, dried over Na2SO4, filtered and the solvent evaporated to give 90 mg of the title compound as a white solid. 1H NMR (400 MHz, CDCl3) δ(TMS): 8.12 (s, 1 H), 8.02 (d, J=7.8 Hz, 1 H), 7.76 (d, J=7.8 Hz, 1 H), 7.57 (t, J=7.8 Hz, 1 H), 7.35 (bt, 1 H), 6.96 (bd, 1 H), 4.93 (m, 1 H), 4.51 (m, 1 H), 4.12 (d, J=4.8 Hz, 2 H), 3.03 (m, 1 H), 2.77 (m, 1 H), 2.61 (m, 1 H), 2.31 (bs, 1 H), 2.04 (m, 2 H), 1.80-1.30 (m, 4 H), 1.17 (m, 6 H), 1.08 (d, J=6.2 Hz, 6 H). MS found: (M+H)+=472.36.

Provenance & Evidence