Cornforth reagent → HCID 69285463, compound

Participants

Reaction Steps

To a solution of N-(2-((1R,2S,4R)-2-((S)-1-hydroxy-2-methylpropyl)-4-(isopropyl(methyl)amino)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide (250 mg, 0.53 mmol; See Example 81, Step 6) in CH2Cl2 (15 mL) was added PDC (599 mg, 1.5 mmol), and 4A molecular sieves (excess). The reaction was stirred for 16 h at RT and then filtered, and concentrated in vacuo. The residue was purified by HPLC to N-(2-((1R,2S,4R)-2-isobutyryl-4-(isopropyl(methyl)amino)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide. MS found: (M+H)+=470.

Provenance & Evidence