HCID 68765971, compound → (1R,2S,5R)-tert-butyl 2-amino-7-oxo-6-aza-bicyclo[3.2.1]octane-6-carboxylate

Participants

Reaction Steps

Examples 11p and 11q, Step 1: To a solution of the (1R,2S,5R)-2-benzyloxycarbonylamino-7-oxo-6-aza-bicyclo[3.2.1]octane-6-carboxylic acid tert-butyl ester (8 g, 21.36 mmoles) in 160 ml of methanol was added 1.6 g of 10% Pd/C (50% wet), and it was treated with H2 (52 psi)for 18 hrs. It was filtered through a plug of Celite to remove the catalyst, and the solvent was evaporated off to give (1R,2S,5R)-tert-butyl 2-amino-7-oxo-6-aza-bicyclo[3.2.1]octane-6-carboxylate as a foamy solid, which was used for the next step without purification.

Provenance & Evidence