Hydrogen Bromide → Hydrogen Bromide

Participants

Reaction Steps

To a solution of (1S,2S,4R)-2-(cyanomethyl)-4-(isopropyl(methyl)amino)cyclohexylcarbamate (479 mg) in 4 ml of acetic acid was added 4 ml of 30% HBr in acetic acid, and the mixture was stirred for 2.5 hours. The acid was evaporated off under reduced pressure and residue was dried by azeotroping with benzene several times. The residue was further dried under vacuum to give 2-((1S,2S,5R)-2-amino-5-(isopropyl(methyl)amino)cyclohexyl)acetonitrile as a bis-HBr salt as a solid (673 mg).

Provenance & Evidence