Trifluoroacetic acid → HCID 86596975, compound

Participants

Reaction Steps

To absolution of tert-butyl (1R,3R,4S)-4-((benzyloxycarbonyl)amino)-3-(3-methyl-1,2,4-oxadiazol-5-yl)cyclohexylcarbamate (250 mg) in CH2Cl2 (10 mL) was added TFA (3 mL) at RT. The reaction was stirred for 5 h and concentrated in vacuo. The residue was partitioned between 1N NaOH (30 mL) and EtOAc (40 mL). The aqueous layer was extracted with EtOAc (2×50 mL) and the organic phases were combined, washed with brine (25 mL), dried (Na2SO4), filtered, and concentrated in vacuo to give benzyl (1S,2R,4R)-4-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclohexylcarbamate. MS found: (M+H)+=331.

Provenance & Evidence