Diethyl Ether → HCID 69285596, compound

Participants

Reaction Steps

The entirety of benzyl (1S,2R,4R)-4-(isopropyl(methyl)amino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclohexylcarbamate prepared in Step 2 (270 mg, 0.7 mmol) was charged with 30% HBr/AcOH (5 mL). The reaction vessel warms and a vigorous gas evolution occurs. The mixture was stirred for 25 min at RT and then the flask was placed in a cool water bath before the addition of 20 mL of Et2O. The resulting solid was collected, washed with Et2O twice, and concentrated in vacuo to give (1R,3R,4S)-N1-isopropyl-N1-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)cyclohexane-1,4-diamine (250 mg). MS found: (M+H)+=253.

Provenance & Evidence