Methyl 3-[(3-ethoxyacryloyl)amino]benzoate → Methyl 2-oxo-1,2-dihydroquinoline-5-carboxylate

Participants

Reaction Steps

10 Grams of m-methoxycarbonyl-N-(β-ethoxyacryloyl)aniline was added to 100 ml of concentrated sulfuric acid gradually, and this mixture was stirred at a room temperature for 2 hours, then at 45° C. for 4 hours. The reaction mixture was poured in ice-water, and the precipitated crystals were collected by filtration and were washed with water. Thus obtained crude crystals were recrystallized from methanol-chloroform to obtain 6.97 g of 5-methoxycarbonylcarbostyril.

Provenance & Evidence