Sodium Hydroxide → HCID 19004077, compound

HRID 2225367Notes

Reaction equation

HRID 2225367 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[N:10]=[C:9]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]([O:28]CC)=[O:27])[CH2:20][CH2:19]3)[C:8]=2[CH:31]=1>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[N:10]=[C:9]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])[CH2:22][CH2:23]3)[C:8]=2[CH:31]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19004070HCID 19004070, compound

Product 1

HCID 19004077HCID 19004077, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2N Aqueous sodium hydroxide solution (5 ml) was added to a solution of 2.15 g of ethyl 4-(2-chlorodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinepropionate in 22 ml of methanol. The solution was refluxed for 30 min and then concentrated. The residue was dissolved in hot water and the solution was neutralized with 0.5N hydrochloric acid. The precipitates were collected by filtration to give 1.84 g of pale yellow crystals, which were recrystallized from aqueous ethanol to give pale yellow crystals, mp 120°-121° C.

Workup

  1. temperatureThe solution was refluxed for 30 min
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in hot water
  4. filtrationThe precipitates were collected by filtration

Sources & evidence

ORD record
ord-8092346cb9944302b0362a74650de7a8
Source dataset
uspto-grants-1994_09
Patent number
US05344828

Reaction notes

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