Ethyl chloroformate → HCID 19004083, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.33 g of 6-(1-piperazinyl)-11H-dibenz[b,e]azepine, 1.63 g of ethyl chloroformate and 1.66 g of potassium carbonate in 20 ml of N,N-dimethylformamide was stirred at 80° C. for 3 hrs. Ice water was added to the reaction mixture and extracted with ether. The ether layer was washed with water, dried and concentrated. The residue was chromatographed on silica gel using a mixture of n-hexane and ethyl acetate (1:2) as an eluent to give 3.14 g of colorless crystals, which were recrystallized from isopropyl ether to give colorless prisms, mp 137°-138° C.

Provenance & Evidence