反应详情

2N Aqueous sodium hydroxide solution (5 ml) was added to a solution of 1.68 g of ethyl 2-(1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepin-2-yl)acetate in 17 ml of methanol. The solution was refluxed for 30 min and then concentrated. The residue was dissolved in hot water and the solution was neutralized with 0.5N hydrochloric acid. The precipitates were collected by filtration to give 1.33 g of colorless crystals, which were recrystallized from aqueous ethanol to give colorless needles, mp 162°-163° C.

1. temperatureThe solution was refluxed for 30 min
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in hot water
4. filtrationThe precipitates were collected by filtration