HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 222540Generated: October 27, 2026
[(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate → HCID 178441709, compound
https://huagongshe.com/reaction/222540
Participants
| Role | Name | HCID | Charge |
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| Reactant | [(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate | HCID 86652101 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178441709 | HCID 178441709 | — |
Reaction Steps
Each diastereomer of [(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate was dissolved in methanol and heated to 70° C. for 2 hours. The residue was purified by HPLC reverse phase (C-18), eluting with acetonitrile/water+0.1% trifluoroacetic acid to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08207208B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-ac4aea16b0544fc79b31442ea2b4e7ca |
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| Source note | uspto-grants-2012_06 |
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