Sodium Iodide → HCID 23175711, compound

Participants

Reaction Steps

A mixture of 3-(diphenylmethoxymethyl)pyrrolidine (267 mg) (Preparation 7), 3,4-methylenedioxyphenethyl bromide (250 mg), sodium carbonate (1.0 g) and sodium iodide (100 mg) in acetonitrile (30 ml) was heated under reflux for 24 hours, diluted with water and ethyl acetate and the layers separated. The organic layer was washed with water, dried over magnesium sulphate and evaporated. The residue was purified by chromatogrpahy on silica using dichloromethane plus 0-20% ethyl acetate followed by dichloromethane plus 20% ethyl acetate plus 1-5% methanol as eluant. Appropriate fractions were combined and evaporated to give the title compound (217 mg) as a colourless oil which was characterised containing 0.25 equivalents of water.

Provenance & Evidence