Hydrochloric Acid → HCID 67850378, compound

Participants

Reaction Steps

1.35 g of methylammonium chloride in 10 ml of toluene is mixed under argon with 7.5 ml of trimethylaluminum in 10 ml of toluene by instillation and stirred for 2 hours at room temperature. 50 mg of the E-methyl ester of example 1 is mixed in 2 ml of toluene with 2 ml of the above-produced reagent. It is stirred for 6 hours at 80° C., then mixed at room temperature with 1M hydrochloric acid and extracted with ether. The acid phase is alkalized with potassium carbonate and extracted with ethyl acetate. After washing with water and drying, the ethyl acetate phase is concentrated by evaporation. 30 mg of the title compound (50%) remains; melting range: 172°-180° C.

Provenance & Evidence