4-Methoxybenzenesulfonyl chloride → HCID 19004259, compound

Participants

Reaction Steps

Following the procedure described in the preceeding examples but using 2-(2,4-dichlorophenyl)-3-amino-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and p-methoxybenzenesulfonylchloride, the title compound was obtained in a similar yield: mp 56°-66° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 8.0-7.5 (m, 4H, arom), 7.3-6.9 (m, 3H, arom.), 5.24 (br s, 1H, NH), 4.96 (AB system, Δv=0.52, J=14.5 Hz, 2H, CH2 -Tr), 3.85 (s, 3H, OMe), 3.55 (dq, Jd =5.2 Hz, Jq =J=14 Hz, 2H, CH2NH), 2.16 (s, 1H, N=CH), 2.03 (s, 1H, N=CH). Anal calcd. for C18H18Cl2N4O4S: C 47.27%; H 3.97%; N 12.25 %. Found: C 47.56%; H 4.08%; N 12.09%.

Provenance & Evidence