2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride → HCID 18957993, compound

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Reaction Steps

Following the procedure described in the preceeding examples but using 2-(2,4-dichlorophenyl)-3-amino-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and 2-nitro-4-trifluromethylbenzenesulfonylchloride, the title compound was obtained in a similar yield: mp 97°-105° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 8.4-7.7 (m, 4H, arom), 7.6-6.9 (m, 3H, arom.), 6.03 (br, t, J=5 Hz, 1H, NH), 4.98 (AB system, Δv=0.66, J=14.5 Hz, 2H, CH2 -Tr), 3.87 (d, J=6Hz, 2H, CH2NH). Anal calcd. for C18H14Cl2F3N5O5S; C 40.01%; H 2.61%; N 12.96%. Found: C 40.34%; H 2.84%; N 12.57%.

Provenance & Evidence