2-Mesitylenesulfonyl chloride → 2-(2,4-Dichlorophenyl)-3-(2,4,6-trimethylbenzenesulfonamido)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Participants

Reaction Steps

Following the procedure described in the preceeding examples but using 3-amino-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and 2,4,6-trimethylbenzenesulfonylchloride, the title compound was obtained in a similar yield: mp 171°-172° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 7.94 (s, 1H, CH=N), 7.80 (s, 1H, CH=N), 7.68 (s, 4H, arom), 7.7-7.0 (m, 3H, arom), 6.88 (s, 2H, arom), 4.93 (AB system, Δv=0.32, J=14.5 Hz, 2H, CH2 -Tr), 3.7-3.3 (m, 2H, CH2NH), 2.54 (s, 6H, 2Me), 2.29 (s, 3H, Me). Anal calcd. for C20H22Cl2N4O3S: C 51.18%; H 4.72%; N 11.94%. Found: C 51.26%; H 4.98%; N 11.92%.

Provenance & Evidence