1-Propanesulfonyl chloride → 2-(2,4-Dichlorophenyl)-3-(propanesulfonamido)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Reaction Steps

Following the procedure described in example 1 but using 3-amino-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and propanesulfonylchloride, the title compound was obtained in a similar yield: mp 128°-129° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 7.99 (s, 1H, CH=N), 7.83 (s, 1H, CH=N), 7.62 (d, J=8.5 Hz, 1H, arom), 7.4-7.1 (m, 2H, arom), 5.00 (AB system, Δv=0.56, J=14.5 Hz, 2H, CH2 -Tr), 4.91 (m, 1H, NH, 4.1-3.5 (m, 2H, CH2NH), 3.1-2.8 (m, 2H, CH2S), 2.1-1.5 (m, 2H, CH2CH2S), 1.00 (t, J=7.5 Hz, 3H, Me). Anal calcd. for C14H18Cl2N4O3S: C 42.76%; H 4.61%; N 14.25%. Found: C 42.61%; H 4.77%; N 14.08%.

Provenance & Evidence