2-Acetamido-1,3-thiazole-5-sulfonyl chloride → 3-(2-Acetamido-5-thiazolesulfonamido)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Participants

Reaction Steps

Following the procedure described in the preceeding examples but using 3-amino-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and 2-acetamido-5-thiazolesulfonylchloride, the title compound was obtained in a similar yield: mp 96°-112° C.; 1H NMR (80 MHz, MeOH-d4)δ(TMS) 8.27 (s, 1H, CH=N), 7.74 (s, 1H, CH=N), 7.55 (d, J=8.5 Hz, 1H, arom), 7.3-7.1 (m, 2H, arom), 4.80 (AB system, Δv=0.35, J=14.5 Hz, 2H, CH2 -Tr), 3.74 (AB system, Δv=0.36, J=13.8Hz, 2H, CH2NH), 2.37 (s, 1H, Me), 2.22 (s, 1H, Me). Anal calcd. for C17H18Cl2N6O4S2 : C 40.40%; H 3.59%; N 16.63%. Found: C 40.69%; H 4.06%; N 16.70 %.

Provenance & Evidence