4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 18957986, compound

Participants

Reaction Steps

Following the procedure described in the preceeding examples but using 3-amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and 4-trifluoromethylbenzenesulfonylchloride, the title compound was obtained in a similar yield: mp 161°-162° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 8.04 (s, 1H, N=CH), 7.77 (s, 1H, N=CH), 8.0-6.5 (m, 7H, atom), 5.35 (br t, 1H, NH), 4.75 (AB system, Δv=0.098, J=14.6 Hz, 2H, CH2 -Tr), 3.8-3.1 (m, 2H, NCH2). Anal. calcd. for C18H15F5N4O3S: C 46.76%; H 3.27%; N 12.12%. Found: C 47.04%; H 3.29%; N 12.07%.

Provenance & Evidence