Methylamine → HCID 18958006, compound

Participants

Reaction Steps

A solution containing 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane (5.5 g, 20.4 mmol), obtained as explained in EP 106515, a 40% solution of methylamine in ethanol (60 mL) and ethanol is stirred at 100° C. for 16 h in a closed vessel. The product is isolated by flash chromatography as a white solid. mp 98°-101° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 8.12 (s, 1H, N=CH), 7.81 (s, 1H, N=CH), 7.73 (d, J=8.5 Hz, 1H, arom), 7.5-7.1 (m, 2H, arom), 4.78 (s, 2H, CH2 -Tr), 3.28 (AB system, Δv=0.49, J=12.3 Hz, 2H, NCH2), 2.29 (s, 3H, NMe).

Provenance & Evidence